(2R)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid

(2R)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid - Names and Identifiers

Name	(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
Synonyms	N-Boc-piperazine-2-carboxylic acid (R)-4-Boc-Piperazine-3-carboxylicacid (R)-1-Boc-piperazine-2-carboxylic acid 1-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID (R)-4-Boc-Piperazine-3-carboxylic acid (R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (2R)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid (R)-1-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID (R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 1,2-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2R)-
CAS	278788-60-6
InChI	InChI=1/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-6-7(12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)/t7-/m1/s1

(2R)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid - Physico-chemical Properties

Molecular Formula	C10H18N2O4
Molar Mass	230.26
Density	1.193±0.06 g/cm3(Predicted)
Melting Point	243-247 ºC (DEC.)
Boling Point	371.8±37.0 °C(Predicted)
Flash Point	178.6°C
Vapor Presure	1.5E-06mmHg at 25°C
pKa	2.90±0.20(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,2-8°C
Refractive Index	1.495

(2R)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

(2R)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid - Introduction

(R)-PIPERAZINE-1,2-dicarboxylic ACID 1-TERT-BUTYL ESTER ((R)-PIPERAZINE-1,2-dicarboxylic ACID 1-TERT-BUTYL ESTER) is an organic compound with the molecular formula C12H21NO4.

Nature:
(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER is a white crystalline solid with low solubility. It is a hydrophobic compound, soluble in Alcohols, Ketones and organic solvents, and relatively stable under regular laboratory conditions.

Use:
(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER is commonly used as condensation reagent, protecting group and intermediate in organic synthesis. It can be used to synthesize amino acids, peptides and other organic molecules. In addition, it can also be used to prepare organic compounds such as drugs and ligands.

Method:
(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER can be obtained by the substitution reaction of PIPERAZINE. First, piperazine is reacted with formic acid to give piperazine-2-carboxylic acid. Then, an esterification reaction is carried out using T-butanol to introduce a t-butyl alcohol group into a formic acid moiety to give the final compound.

Safety Information:
(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER generally does not pose a direct threat to human health under normal conditions of use. However, as a chemical, it still needs to be handled with caution. When used, follow appropriate laboratory procedures and follow the recommendations provided in the safety data sheet. During storage and handling, avoid contact with oxidants, strong acids, strong alkalis and open flames.

Last Update：2024-04-09 21:01:54